Major Milestones
Developing Regenerative Medicine and Creating a Future Star in the Biomedical Industry
To repair damaged or aging organs and tissues to prolong life, the biomedical community rushed to investigate regenerative medicine, which utilizes the regenerative properties of cells. Following the success of cell replication technology and the discovery of stem cells in the 1950s, the direction of regenerative medicine-related research had been set. However, it was not until the introduction of bone marrow transplantation technology in the 1980s that Taiwan began researching regenerative medicine. In 1999, ITRI focused on researching and developing biomedical engineering technology, developing regenerative medicine from the aspects of materials and biological science.
In the 2000s, ITRI learned regenerative medicine (e.g., stem cells, bone repair, and cell culture) from overseas to overcome obstacles for this field in Taiwan. In 2002, ITRI, BioGend Therapeutics, and National Taiwan University Hospital co-researched and co-developed the technology of repairing cartilage and bone joints using two-phase materials, and in 2008 transferred said technology (via exclusive license) to Exactech Taiwan, a subsidiary of Exactech, the fifth largest artificial joint company in the United States. The transfer set a record for the highest technology transfer royalty rates in the field of biomedicine at the time. In 2005, ITRI established Taiwan’s first-ever cell production laboratory, becoming a key promoter of cell therapy. In 2017, ITRI introduced the Cytotwister disposable cell mass production bioreactor technology, greatly improving cell production capacity and quality. In 2019, ITRI developed the world’s first-ever biomimetic knobby magnetic beads iKNOBEADS to treat cancer. In 2021, ITRI launched the Automated Cell Production System, giving birth to Taiwan’s first-ever automated cell factory that can be widely used in areas such as cell therapy, cell tissue regeneration, and cell tissue repair. During that same year, ITRI introduced the 3D Printing Biomimetic Materials and Structures for Tissue Integration (BioMS-Ti) that accelerates tissue integration and repair, which was transferred to Ingrowth Biotech. In 2022, ITRI developed the Cell Sheet Biomedical Material Integration System, expediting the development of Taiwan’s cell therapy-related regenerative medicine. ITRI is committed to building Taiwan’s regenerative medicine technology and assisting industries to emerge on the international stage.